Article

Stiffness Regulates Intestinal Stem Cell Fate

2021-04-14

Abstract excerpt

<title>Abstract</title> <p>Little is known about how the fibrotic gut stiffening caused by inflammatory bowel diseases (IBD) directs the fate of intestinal stem cells (ISCs). To address this question we first developed a novel long-term culture of quasi-3D gut organoids plated on hydrogel matrix of varying stiffness. Stiffening from 0.6kPa to 9.6kPa significantly reduces Lgr5high ISCs and Ki67+ progenitor cells w...

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Literature Corpus work: 55c76ba2-7e85-51d0-9173-2ff23541e81b
DOI: 10.21203/rs.3.rs-362156/v1

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