Article

An Autoimmune Transcriptional Circuit Driving Foxp3 <sup>+</sup> Regulatory T cell Dysfunction

2022-12-03

Abstract excerpt

Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. While CD4 + Foxp3 + regulatory T cells (Tregs) play a central role in preventing autoimmunity, the molecular mechanism underlying their dysfunction is unknown. Here, we performed comprehensive transcriptomic and epigenomic profiling of Tregs in the autoimmune disease multiple sclerosis (MS) to...

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Literature Corpus work: f3d4363f-3813-5661-b962-fdd43afe38e4
DOI: 10.1101/2022.12.02.518871

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