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Dissection of the microRNA transcriptomes of CD4 <sup>+</sup> T cell subsets in autoimmune inflammation identifies novel regulators of disease pathogenesis

2025-06-27

Abstract excerpt

MicroRNAs (miRNAs) are key regulators of CD4 + T cell differentiation, but how they contribute to the course of an autoimmune disease in vivo remains poorly studied. Given the known roles in autoimmunity of pro-inflammatory T helper 1 (Th)1 and Th17 cells, and anti-inflammatory Foxp3 + regulatory cells, we established a triple reporter mouse for Ifng , Il17 and Foxp3, and subjected it to experimental autoimm...

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Literature Corpus work
20998d09-25ee-5161-90a4-2ad063027090
DOI
10.1101/2025.06.23.661017
Open publication

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Dissection of the microRNA transcriptomes of CD4 <sup>+</sup> T cell subsets in autoimmune inflammation identifies novel regulators of disease pathogenesisDOI 10.1101/2025.06.23.661017
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