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Article

An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.

Nature communications - 3 Mar 2023

Wang Zhao, Liang Qian, Qian Xinyi, Hu Bolang, Zheng Zhanye, Wang Jianhua, Hu Yuelin, Bao Zhengkai, Zhao Ke, Zhou Yao, Feng Xiangling, Yi Xianfu, Li Jin, Shi Jiandang, Liu Zhe, Hao Jihui, Chen Kexin, Yu Ying, Sham Pak Chung, Lu Wange, Wang Xiaoyan, Song Weihong, Li Mulin Jun

Abstract excerpt

Genetic sharing is extensively observed for autoimmune diseases, but the causal variants and their underlying molecular mechanisms remain largely unknown. Through systematic investigation of autoimmune disease pleiotropic loci, we found most of these shared genetic effects are transmitted from regulatory code. We used an evidence-based strategy to functionally prioritize causal pleiotropic variants and identify...

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Share to Alleles
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmunity

Share to Chromatin

Share to DNA-Binding Proteins

Share to Interferon Regulatory Factors

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 36869052
DOI: 10.1038/s41467-023-36897-z
PMCID: PMC9984425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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