Article

Using energy to go downhill – a genoprotective role for ATPase activity in DNA topoisomerase II

2023-06-27

Abstract excerpt

<h4> S ummary </h4> Type II topoisomerases effect topological changes in DNA by cutting a single duplex, passing a second duplex through the break, and resealing the broken strand in an ATP-coupled reaction. Curiously, most type II topoisomerases (topos II, IV, and VI) catalyze DNA transformations that are energetically favorable, such as the removal of superhelical strain; why ATP is required for such reaction...

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Literature Corpus work: f3c3302a-e721-5abd-90f2-c8ca875ab2b9
DOI: 10.1101/2023.06.27.546777

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