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Article

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide.

Science (New York, N.Y.) - 22 Jul 2011

Wu Chyuan-Chuan, Li Tsai-Kun, Farh Lynn, Lin Li-Ying, Lin Te-Sheng, Yu Yu-Jen, Yen Tien-Jui, Chiang Chia-Wang, Chan Nei-Li

Abstract excerpt

Type II topoisomerases (TOP2s) resolve the topological problems of DNA by transiently cleaving both strands of a DNA duplex to form a cleavage complex through which another DNA segment can be transported. Several widely prescribed anticancer drugs increase the population of TOP2 cleavage complex,...

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Source

Identifiers

PMID: 21778401
DOI: 10.1126/science.1204117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21778401-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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