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Using energy to go downhill—a genoprotective role for ATPase activity in DNA topoisomerase II

25 Nov 2023

Abstract excerpt

Type II topoisomerases effect topological changes in DNA by cutting a single duplex, passing a second duplex through the break, and resealing the broken strand in an ATP-coupled reaction cycle. Curiously, most type II topoisomerases (topos II, IV and VI) catalyze DNA transformations that are energetically favorable, such as the removal of superhelical strain; why ATP is required for such reactions is unknown....

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PMID: 38038260
DOI: 10.1093/nar/gkad1157

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