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Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II

30 Jan 2023

Abstract excerpt

Etoposide is a broadly employed chemotherapeutic and eukaryotic topoisomerase II poison that stabilizes cleaved DNA intermediates to promote DNA breakage and cytotoxicity. How etoposide perturbs topoisomerase dynamics is not known. Here we investigated the action of etoposide on yeast topoisomerase II, human topoisomerase IIα and human topoisomerase IIβ using several sensitive single-molecule detection methods....

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PMID: 36717711
DOI: 10.1038/s41589-022-01235-9

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