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Article

A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.

The Journal of biological chemistry - 18 Jun 2004

Walker Jerrylaine V, Nitiss Karin C, Jensen Lars H, Mayne Christopher, Hu Tao, Jensen Peter B, Sehested Maxwell, Hsieh Tao, Nitiss John L

Abstract excerpt

Type II DNA topoisomerases are ATP-dependent enzymes that catalyze alterations in DNA topology. These enzymes are important targets of a variety of anti-bacterial and anti-cancer agents. We identified a mutation in human topoisomerase II alpha, changing aspartic acid 48 to asparagine, that has th...

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Identifiers

PMID: 15037624
DOI: 10.1074/jbc.M312314200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15037624-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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