Article

Lack of mTORC2 signaling in CD11c <sup>+</sup> myeloid cells inhibits their migration and ameliorates experimental colitis

2023-04-28

Abstract excerpt

Mammalian target of rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in tissue-resident CD11c + myeloid cells (CD11cRic Δ/Δ ), this study investigated the role of mTOR complex 2 (mTORC2) signaling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signaling CD...

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Literature Corpus work: f3be9524-106d-587a-8ce0-5fd3abb617be
DOI: 10.1101/2023.04.26.537895

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