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Article

LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling.

Nature communications - 22 Oct 2014

Scheffler Julia M, Sparber Florian, Tripp Christoph H, Herrmann Caroline, Humenberger Alexandra, Blitz Johanna, Romani Nikolaus, Stoitzner Patrizia, Huber Lukas A

Abstract excerpt

The receptor tyrosine kinase Flt3 and its ligand are crucial for dendritic cell (DC) homeostasis by activating downstream effectors including mammalian target of Rapamycin (mTOR) signalling. LAMTOR2 is a member of the Ragulator/LAMTOR complex known to regulate mTOR and extracellular signal-regulated kinase activation on the late endosome as well as endosomal biogenesis. Here we show in mice that conditional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25336251
DOI: 10.1038/ncomms6138
PMCID: PMC4220488

Genes

LAMTOR2
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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