Article

Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in Systemic Lupus Erythematosus

2024-08-04

Abstract excerpt

<h4>Objective</h4> We aim to explore the role of mechanistic target of rapamycin complex (mTORC) 2 in systemic lupus erythematosus (SLE) development, the in vivo regulation of mTORC2 by type I interferon (IFN) signaling in autoimmunity, and to use mTORC2 targeting therapy to ameliorate lupus-like symptoms in an in vivo lupus mouse model and an in vitro coculture model using human PBMCs. <h4>Method</h4> We fi...

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Literature Corpus work: ee1a0962-c1f9-5171-9903-61e6ae873d48
DOI: 10.1101/2024.08.01.606069

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