Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice

30 Nov 2015

Abstract excerpt

Intestinal stem cells (ISCs) drive small intestinal epithelial homeostasis and regeneration. Mechanistic target of rapamycin (mTOR) regulates stem and progenitor cell metabolism and is frequently dysregulated in human disease, but its physiologic functions in the mammalian small intestinal epithelium remain poorly defined. We disrupted the genes mTOR, Rptor, Rictor, or both Rptor and Rictor in mouse ISCs,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26631481
DOI: 10.1096/fj.15-278606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in micePMID 26631481Read ↗

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem CellsSemantic proximity Read ↗

Regulation of colonic epithelial cell homeostasis by mTORC1.Semantic proximity Read ↗

Modulation of intestinal stem cell homeostasis by nutrients: a novel therapeutic option for intestinal diseasesSemantic proximity Read ↗

Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrientsSemantic proximity Read ↗

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in miceSemantic proximity Read ↗

Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesisSemantic proximity Read ↗

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.Semantic proximity Read ↗

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.Semantic proximity Read ↗

Mitochondrial function controls intestinal epithelial stemness and proliferationSemantic proximity Read ↗

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.Semantic proximity Read ↗

Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survivalSemantic proximity Read ↗

Lack of mTORC2 signaling in CD11c <sup>+</sup> myeloid cells inhibits their migration and ameliorates experimental colitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.