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Article

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

6 Oct 2016

Abstract excerpt

mTOR signaling controls several critical cellular functions and is deregulated in many cancers, including pancreatic cancer. To date, most efforts have focused on inhibiting the mTORC1 complex. However, clinical trials of mTORC1 inhibitors in pancreatic cancer have failed, raising questions about this therapeutic approach. We employed a genetic approach to delete the obligate mTORC2 subunit Rictor and identified...

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PMID: 27758884
DOI: 10.1158/0008-5472.can-16-0810

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