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Article

Regulation of colonic epithelial cell homeostasis by mTORC1.

Scientific reports - 14 Aug 2020

Kotani Takenori, Setiawan Jajar, Konno Tasuku, Ihara Noriko, Okamoto Saki, Saito Yasuyuki, Murata Yoji, Noda Tetsuo, Matozaki Takashi

Abstract excerpt

Cell signaling important for homeostatic regulation of colonic epithelial cells (CECs) remains poorly understood. Mammalian target of rapamycin complex 1 (mTORC1), a protein complex that contains the serine-threonine kinase mTOR, mediates signaling that underlies the control of cellular functions such as proliferation and autophagy by various external stimuli. We here show that ablation of tuberous sclerosis...

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Identifiers

PMID: 32796887
DOI: 10.1038/s41598-020-70655-1
PMCID: PMC7427982

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