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Article

mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.

Immunobiology - 1 Feb 2017

Paschoal Vivian A, Amano Mariane T, Belchior Thiago, Magdalon Juliana, Chimin Patricia, Andrade Maynara L, Ortiz-Silva Milene, Castro Érique, Yamashita Alex S, Rosa Neto José Cesar, Câmara Niels O, Festuccia William T

Abstract excerpt

Genetic- and diet-induced obesity and insulin resistance are associated with an increase in mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue. We investigated herein the effects of pharmacological mTORC1 inhibition in the development of adipose tissue inflammation induced by high-fat diet (HFD) feeding, as well as in the polarization, metabolism and function of bone marrow-derived...

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PMID: 27692982
DOI: 10.1016/j.imbio.2016.09.014

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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