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Article

Rack1 maintains intestinal homeostasis by protecting the integrity of the epithelial barrier.

American journal of physiology. Gastrointestinal and liver physiology - 1 Feb 2018

Cheng Zhuan-Fen, Cartwright Christine A

Abstract excerpt

Previously, we generated mouse models of Rack1 deficiency to identify key functions for Rack1 in regulating growth of intestinal epithelia: suppressing crypt cell proliferation and regeneration, promoting differentiation and apoptosis, and repressing development of neoplasia. However, other than low body weight, we did not detect an overt phenotype in mice constitutively deleted of Rack1 in intestinal epithelia (...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29025732
DOI: 10.1152/ajpgi.00241.2017
PMCID: PMC5866421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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