Article

Investigating right-sided colon cancer and the involvement of inflammation, the microbiome, and foetal stem cell-like plasticity

2021-01-01

Abstract excerpt

Human right-sided colorectal cancer (CRC) has a poor prognosis and distinct mutational profile compared with left-sided CRC. Indeed right-sided CRCs are associated with BRAF mutations and aberrations in both the mismatch repair and TGFb signalling pathways, whilst left-sided CRCs are associated with APC and TP53 mutations. In chapter III I establish a mouse model of right-sided colon cancer driven by activation of...

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Literature Corpus work: f3bac3e0-79a9-5883-9cdd-c8f4444381c9
DOI: 10.5525/gla.thesis.81917

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