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Article

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

27 Apr 2022

Abstract excerpt

Tumours are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in affecting tumour growth is well established, the impact of mutant cancer cells on healthy surrounding tissues remains poorly defined. Here, using mouse intestinal organoids, we uncover a paracrine mechanism by which intestinal cancer cells reactivate foetal and...

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PMID: 35543624
DOI: 10.7554/elife.76541

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