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Article

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.

Oncogene - 1 Sept 2020

Reischmann Nadine, Andrieux Geoffroy, Griffin Ricarda, Reinheckel Thomas, Boerries Melanie, Brummer Tilman

Abstract excerpt

BRAFV600E confers poor prognosis and is associated with a distinct subtype of colorectal cancer (CRC). Little is known, however, about the genetic events driving the initiation and progression of BRAFV600E mutant CRCs. Recent genetic analyses of CRCs indicate that BRAFV600E often coexists with alterations in the WNT- and p53 pathways, but their cooperation remains ill-defined. Therefore, we systematically...

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Identifiers

PMID: 32792685
DOI: 10.1038/s41388-020-01414-9
PMCID: PMC7498370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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