Article

Epithelial states in colorectal cancer are co-determined by YAP associated fetal programming and WNT signaling

2025-06-06

Abstract excerpt

<title>Abstract</title> <p>In the colonic epithelium, fetal programming is induced by Yes-associated protein (YAP) signaling, which is associated with tumorigenesis and progression in colorectal cancer (CRC). While CRC was long considered a WNT driven disease, here we show that fetal programmed cells with activated YAP signaling can arise independently of WNT activation. Fetal programmed cells, in the presence of...

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Literature Corpus work: 73c15e3a-4bb1-5430-8c99-0892e405637c
DOI: 10.21203/rs.3.rs-6812365/v1

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