Article

Investigating the impact of intestinal stem cell dynamics on tumour initiation

2019-01-01

Abstract excerpt

In the intestines of mammals, crypt structures are known to house the intestinal Stem Cells (SCs). These intestinal SCs compete with each other at the base of each crypt, and consequently the parameters of SC competition determine the accumulation of mutations within the intestinal tract. I used genetically engineered mouse models to investigate the functional impact of SC competition on tumour formation and propo...

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Literature Corpus work: 7cf5d20a-05a3-5da2-8d52-02b52ae4528d
DOI: 10.5525/gla.thesis.40952

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