Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.

doi:10.1038/s41467-021-23717-5

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Article

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis.

Nature communications - 8 Jun 2021

Leach Joshua D G, Vlahov Nikola, Tsantoulis Petros, Ridgway Rachel A, Flanagan Dustin J, Gilroy Kathryn, Sphyris Nathalie, Vázquez Ester G, Vincent David F, Faller William J, Hodder Michael C, Raven Alexander, Fey Sigrid, Najumudeen Arafath K, Strathdee Douglas, Nixon Colin, Hughes Mark, Clark William, Shaw Robin, van Hooff Sander R, Huels David J, Medema Jan Paul, Barry Simon T, Frame Margaret C, Unciti-Broceta Asier, Leedham Simon J, Inman Gareth J, Jackstadt Rene, Thompson Barry J, Campbell Andrew D, Tejpar Sabine, Sansom Owen J

Abstract excerpt

Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we describe a mouse model of right-sided colon cancer driven by oncogenic BRAF and loss of epithelial TGFβ-receptor signalling. The proximal colonic tumours that develop in this model exhibit a foetal-like...

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PMID: 34103493
DOI: 10.1038/s41467-021-23717-5
PMCID: PMC8187652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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