Article

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> N-terminal-acetyltransferases catalyze N-terminal acetylation (Nt-acetylation), an evolutionarily conserved co-translational modification. Nt-acetylation regulates diverse signaling pathways, yet little is known about its effects in the heart. To gain insights, we studied NAA10-related syndrome, in which mutations in NAA10, which catalyzes Nt-acetylation, causes severe QT pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fc19f81-44f6-5407-ac0a-594b3d96c475
DOI: 10.1101/2023.07.02.546740

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathyDOI 10.1101/2023.07.02.546740Read

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathySemantic proximity Read

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathySemantic proximity Read

Cardiological Manifestations in Males and Females Affected by NAA10 -Related Disease.Semantic proximity Read

A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy.Semantic proximity Read

Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for <i>LMNA</i> -related CardiomyopathySemantic proximity Read

Mechanisms of Congenital Heart Disease Caused by NAA15 HaploinsufficiencySemantic proximity Read

Variants in NAA15 cause pediatric hypertrophic cardiomyopathy.Semantic proximity Read

The Cardiovascular Manifestations and Management Recommendations for Ogden Syndrome.Semantic proximity Read

NAA10-related syndromeSemantic proximity Read

The Cardiovascular Manifestations and Management Recommendations for Ogden SyndromeSemantic proximity Read

A repository of Ogden syndrome patient derived iPSC lines and isogenic pairs by X-chromosome screening and genome-editingSemantic proximity Read

Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency.Semantic proximity Read