Article

Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy

2024-07-19

Abstract excerpt

<title>Abstract</title> <p>N-terminal-acetyltransferases including NAA10 catalyze N-terminal acetylation (Nt-acetylation), an evolutionarily conserved co-translational modification. Little is known about the role of Nt-acetylation in cardiac homeostasis. To gain insights, we studied a novel NAA10 variant (p.R4S) segregating with QT-prolongation, cardiomyopathy and developmental delay in a large kindred. Here we s...

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Literature Corpus work: f08860e9-3b35-5c34-b596-e0fe8cd41134
DOI: 10.21203/rs.3.rs-3398860/v1

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