Article

Mitigation of Injury from Myocardial Infarction by TH1834, an Inhibitor of the Acetyltransferase Tip60

2021-11-11

Abstract excerpt

<h4>ABSTRACT</h4> It is estimated that up to one billion cardiomyocytes (CMs) can be lost during myocardial infarction (MI), which results in contractile dysfunction, adverse ventricular remodeling, and systolic heart failure. Pharmacologic strategies that target factors having both pro-apoptotic and anti-proliferative functions in CMs may be useful for the treatment of ischemic heart disease. One such multifunct...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cb6119d-454b-5104-9e99-e924f19943d5
DOI: 10.1101/2021.11.09.467996

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitigation of Injury from Myocardial Infarction by TH1834, an Inhibitor of the Acetyltransferase Tip60DOI 10.1101/2021.11.09.467996Read

Loss of Tip60-dependent H2A.Z acetylation reprograms cardiomyocyte identity toward a regenerative stateSemantic proximity Read

Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality.Semantic proximity Read

Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarctionSemantic proximity Read

Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosisSemantic proximity Read

Targeting cancer using KAT inhibitors to mimic lethal knockouts.Semantic proximity Read

KAT2A-targeted inhibition prevents an inflammatory response to protect the myocardiumSemantic proximity Read

Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systemsSemantic proximity Read

Histone deacetylase inhibition in the treatment of heart diseaseSemantic proximity Read

Cardiac histone acetylation – therapeutic opportunities aboundSemantic proximity Read

Myeloid STING restrains cardiac remodeling by suppressing macrophage amyloid precursor proteinSemantic proximity Read

Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac diseaseSemantic proximity Read

Histone deacetylases as therapeutic targets — From cancer to cardiac diseaseSemantic proximity Read