Article

GATA3 mutation disrupts a functional network governed by estrogen receptor, FOXA1 and GATA3

2019-05-30

Abstract excerpt

Estrogen receptors (ER) are part of the nuclear receptor superfamily of transcription factors and are activated by the steroid hormone 17β-estradiol. ER forms a regulatory network in conjunction with other transcription factors, such as FOXA1 and GATA3. GATA3 has been identified as one of the most frequently mutated genes in breast cancer and is capable of specifying chromatin localization of FOXA1 and ER. How GAT...

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Literature Corpus work: f3af8292-a7b3-5895-b141-3a7b8b0ae5db
DOI: 10.1101/654871

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