Article
Mutant GATA3 Actively Promotes the Growth of Normal and Malignant Mammary Cells.
Anticancer research - 1 Aug 2018
Emmanuel Natasha, Lofgren Kristopher A, Peterson Esther A, Meier David R, Jung Eric H, Kenny Paraic A
Abstract excerpt
BACKGROUND/AIM: GATA3, a transcription factor expressed in luminal breast epithelial cells, is required for mammary gland development. Heterozygous GATA3 mutations occur in up to 15% of estrogen receptor (ER)-positive breast tumors and have been proposed to be null alleles resulting in haploinsufficiency; however, the mutation spectrum of GATA3 in breast cancer is in sharp contrast to that found in HDR syndrome,...
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