Article
The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver.
Oncogene - 1 Aug 2020
Hruschka Natascha, Kalisz Mark, Subijana Maria, Graña-Castro Osvaldo, Del Cano-Ochoa Francisco, Brunet Laia Paré, Chernukhin Igor, Sagrera Ana, De Reynies Aurelien, Kloesch Bernhard, Chin Suet-Feung, Burgués Octavio, Andreu David, Bermejo Begoña, Cejalvo Juan Miguel, Sutton Joe, Caldas Carlos, Ramón-Maiques Santiago, Carroll Jason S, Prat Aleix, Real Francisco X, Martinelli Paola
Abstract excerpt
As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 is a paradigm of this. We investigated the functions of the most common GATA3 mutation (X308_Splice) and five additional mutations, which converge into a neoprotein that we called "neoGATA3," associated...
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