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Article

Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover.

BMC cancer - 22 Apr 2014

Adomas Aleksandra B, Grimm Sara A, Malone Christine, Takaku Motoki, Sims Jennifer K, Wade Paul A

Abstract excerpt

BACKGROUND: The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory program driving tumor growth. GATA3 mutations are frequent in breast cancer and have been classified as driver mutations. To elucidate the contribution(s) of GATA3 alterations to cancer, we studied two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24758297
DOI: 10.1186/1471-2407-14-278
PMCID: PMC4021073

Genes

GATA3
FOXA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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