Article
Mutation of GATA3 in human breast tumors.
Oncogene - 7 Oct 2004
Usary Jerry, Llaca Victor, Karaca Gamze, Presswala Shafaq, Karaca Mehmet, He Xiaping, Langerød Anita, Kåresen Rolf, Oh Daniel S, Dressler Lynn G, Lønning Per E, Strausberg Robert L, Chanock Stephen, Børresen-Dale Anne-Lise, Perou Charles M
Abstract excerpt
GATA3 is an essential transcription factor that was first identified as a regulator of immune cell function. In recent microarray analyses of human breast tumors, both normal breast luminal epithelium and estrogen receptor (ESR1)-positive tumors showed high expression of GATA3. We sequenced genomic DNA from 111 breast tumors and three breast-tumor-derived cell lines and identified somatic mutations of GATA3 in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.