Article

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

2019-06-08

Abstract excerpt

As the catalogue of oncogenic driver mutations is expanding, it is becoming clear that alterations in a given gene should not be lumped into one single class, since they might have different functions. The transcription factor GATA3 is a paradigm of this. Here, we address the functions of the most common GATA3 mutation (X308_Splice) which generates a neoprotein that we designate as neoGATA3, associated with good...

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Literature Corpus work: e8932d58-23b2-52f6-9f14-cff95e54d1cc
DOI: 10.1101/664367

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