Article
Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer.
Breast cancer research : BCR - 20 Nov 2014
Cohen Helit, Ben-Hamo Rotem, Gidoni Moriah, Yitzhaki Ilana, Kozol Renana, Zilberberg Alona, Efroni Sol
Abstract excerpt
INTRODUCTION: GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers. Here, we focused on its function in luminal breast cancer, where GATA3 is frequently mutated, and its levels are significantly elevated. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.