Article

Trajectories of neurodegeneration and seed amplification biomarkers prior to disease onset in individuals at risk of prion disease

2022-11-01

Abstract excerpt

Human prion diseases are remarkable for long incubation times followed by typically rapid clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are remarkably useful in the clinical phase, but their potential to predict clinical onset in healthy people remains unclear. This is relevant not only to the design of preventive strategies in those at-risk of prion diseases, but more broad...

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Literature Corpus work: f3ae9442-629f-5fde-b00e-ebf926047fd1
DOI: 10.1101/2022.10.30.22281644

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