Article

Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease

2019-12-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Fluid biomarkers are important in the development of therapeutics to delay or prevent prion disease, but have not been systematically evaluated in pre-symptomatic individuals at risk for genetic prion disease. <h4>METHODS</h4> We recruited pre-symptomatic individuals with pathogenic mutations in the prion protein gene ( PRNP ; N=27) and matched controls (N=16), to donate cereb...

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Literature Corpus work: f50d939d-2347-5831-b77a-e9497ed864f3
DOI: 10.1101/2019.12.13.19014217

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