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Article

Characteristic CSF prion seeding efficiency in humans with prion diseases.

Molecular neurobiology - 1 Feb 2015

Cramm Maria, Schmitz Matthias, Karch André, Zafar Saima, Varges Daniela, Mitrova Eva, Schroeder Bjoern, Raeber Alex, Kuhn Franziska, Zerr Inga

Abstract excerpt

The development of in vitro amplification systems allows detecting femtomolar amounts of prion protein scrapie (PrP(Sc)) in human cerebrospinal fluid (CSF). We performed a CSF study to determine the effects of prion disease type, codon 129 genotype, PrP(Sc) type, and other disease-related factors...

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Source

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Identifiers

PMID: 24809690
DOI: 10.1007/s12035-014-8709-6
PMCID: PMC4309904

Genes

PRNP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24809690-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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