Article

Evaluation of plasma tau and neurofilament light chain biomarkers in a 12-year clinical cohort of human prion diseases

2020-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Prion diseases are fatal neurodegenerative conditions with highly accurate CSF and imaging diagnostic markers, but major unmet needs for blood biomarkers. Using ultrasensitive immuno-assays, we measured tau and neurofilament light chain (NfL) protein concentrations in 709 plasma samples taken from 377 individuals with prion disease during a 12-year prospective clinical study, alongside healthy an...

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Literature Corpus work: 95cdcf76-65d3-515c-a9c8-4a24886dfff6
DOI: 10.1101/2020.07.27.20157594

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