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Article

Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.

Acta neuropathologica - 1 Apr 2021

Sokratian Arpine, Ziaee Julia, Kelly Kaela, Chang Allison, Bryant Nicole, Wang Shijie, Xu Enquan, Li Joshua Y, Wang Shih-Hsiu, Ervin John, Swain Sandip M, Liddle Rodger A, West Andrew B

Abstract excerpt

α-Synuclein aggregation underlies pathological changes in Lewy body dementia. Recent studies highlight structural variabilities associated with α-synuclein aggregates in patient populations. Here, we develop a quantitative real-time quaking-induced conversion (qRT-QuIC) assay to measure permissive α-synuclein fibril-templating activity in tissues and cerebrospinal fluid (CSF). The assay is anchored through...

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Identifiers

PMID: 33641009
DOI: 10.1007/s00401-021-02288-1
PMCID: PMC8055043

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