Article
Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.
Annals of neurology - 1 Jan 2017
Foutz Aaron, Appleby Brian S, Hamlin Clive, Liu Xiaoqin, Yang Sheng, Cohen Yvonne, Chen Wei, Blevins Janis, Fausett Cameron, Wang Han, Gambetti Pierluigi, Zhang Shulin, Hughson Andrew, Tatsuoka Curtis, Schonberger Lawrence B, Cohen Mark L, Caughey Byron, Safar Jiri G
Abstract excerpt
OBJECTIVE: Several prion amplification systems have been proposed for detection of prions in cerebrospinal fluid (CSF), most recently, the measurements of prion seeding activity with second-generation real-time quaking-induced conversion (RT-QuIC). The objective of this study was to investigate the diagnostic performance of the RT-QuIC prion test in the broad phenotypic spectrum of prion diseases. METHODS: We...
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