Article

Biomarker changes preceding symptom onset in genetic prion disease

2023-12-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> Genetic prion disease is a universally fatal and rapidly progressive neurodegenerative disease for which genetically targeted therapies are currently under development. Preclinical proofs of concept indicate that treatment before symptoms will offer outsize benefit. Though early treatment paradigms will be informed by the longitudinal biomarker trajectory of mutation carrier...

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Literature Corpus work: bac21574-b633-5d22-b498-25d52194fde7
DOI: 10.1101/2023.12.18.23300042

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