Article

Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remission

2026-03-02

Abstract excerpt

<h4>Objective</h4> To define cellular and molecular mechanisms distinguishing active systemic lupus erythematosus (SLE) from remission by profiling autoreactive antinuclear antigen– positive (ANA+) and non-autoreactive B cells subsets in three cohorts: active disease (SLE-A), long-term, drug free remission (SLE-R), and healthy controls (HC). <h4>Methods</h4> Peripheral blood B cells were phenotyped by flow cytom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3ae8315-abbd-5656-80c2-b674b756bc01
DOI: 10.64898/2026.02.27.708589

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remissionDOI 10.64898/2026.02.27.708589Read

IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodiesSemantic proximity Read

Inactive disease in lupus patients is linked to autoantibodies to type-I interferons that normalize blood IFNα and B cell subsetsSemantic proximity Read

Single-cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosusSemantic proximity Read

Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosusSemantic proximity Read

Type I interferon drives dysfunction of a distinct CD8+ HLA-DRB1+ T cell subset in systemic lupus erythematosusSemantic proximity Read

Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathologySemantic proximity Read

Unraveling transcriptomic signatures and dysregulated pathways in systemic lupus erythematosus across disease statesSemantic proximity Read

Uncovering Immune Surveillance Deficiency in B Cell-Driven Autoimmune DiseaseSemantic proximity Read

Cochlin-Expressing Memory B (COMB) Cells Are Enriched in Autoimmune Diseases and Display a Distinct Activation ProfileSemantic proximity Read

A dynamic activation–memory cycle organizes the human IgG⁺ memory B cell compartmentSemantic proximity Read

Tracking clonal dynamics of CD8 T cells and immune dysregulation in progression of systemic lupus erythematosus with nephritisSemantic proximity Read

Cell-type-specific transcriptome architecture underlying the establishment and exacerbation of systemic lupus erythematosusSemantic proximity Read