Article

Inactive disease in lupus patients is linked to autoantibodies to type-I interferons that normalize blood IFNα and B cell subsets

2021-04-07

Abstract excerpt

Systemic Lupus Erythematosus (SLE) is characterized by a prominent increase in expression of type-I interferon (IFN)-regulated genes in 50-75% of patients. Here we investigate the presence of autoantibodies (auto-Abs) against type I IFN in SLE patients and their possible role in controlling disease severity. We report that out of 491 SLE patients, 66 had detectable anti-IFNα-auto-Abs. The presence of neutralizing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4173cbe1-fd90-5ae8-abef-c914f62c3374
DOI: 10.1101/2021.04.07.21255049

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inactive disease in lupus patients is linked to autoantibodies to type-I interferons that normalize blood IFNα and B cell subsetsDOI 10.1101/2021.04.07.21255049Read

Mechanistic insights into B-cell activation and autoreactivity regulation in active SLE and remissionSemantic proximity Read

IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodiesSemantic proximity Read

Type I interferon drives dysfunction of a distinct CD8+ HLA-DRB1+ T cell subset in systemic lupus erythematosusSemantic proximity Read

Optimal Selection of IFN-α-Inducible Genes to Determine Type I Interferon Signature Improves the Diagnosis of Systemic Lupus ErythematosusSemantic proximity Read

Cause and consequences of the activated type I interferon system in SLESemantic proximity Read

Increased expression of B cell activation factor supports the abnormal expansion of transitional B cells in systemic lupus erythematosus.Semantic proximity Read

Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus BloodSemantic proximity Read

The interferon signature in autoimmune diseases.Semantic proximity Read

Uncoupling interferons and the interferon signature explain clinical and transcriptional subsets in SLESemantic proximity Read

Type I Interferon Signature Strength Correlates with Alloimmunization-Associated Transcriptomic Programs in Systemic Lupus Erythematosus: A Multi-Cohort AnalysisSemantic proximity Read

Patterns of ANA+ B cells for SLE patient stratificationSemantic proximity Read

B cells in systemic lupus erythematosusSemantic proximity Read