Article

IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodies

2024-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by an array of autoantibodies, in particular anti-nuclear antibodies (ANA). The disease is also hallmarked by an expansion of plasmablasts (PB) in peripheral blood. How these relate to autoantibody production is not clear. Here, we aimed to understand B cell alterations in SLE and their relationship to immunoglobulin level...

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Literature Corpus work: 5887d7f1-5cf9-5aab-9209-5248c05cb6ea
DOI: 10.1101/2024.11.18.624119

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