Article

Cochlin-Expressing Memory B (COMB) Cells Are Enriched in Autoimmune Diseases and Display a Distinct Activation Profile

2025-03-26

Abstract excerpt

Rheumatoid arthritis (RA) is the most common chronic autoimmune arthritis, causing joint damage and affecting multiple organs over time. B cells play a key role in driving the disease by producing autoantibodies, releasing cytokines, and presenting antigens to T cells. While B cell depletion therapies can help reduce inflammation, they remove all CD20+B cells indiscriminately, which can increase infection risk and...

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Literature Corpus work: 3bc89fec-f650-5a4d-8da2-57d31e5b936c
DOI: 10.1101/2025.03.24.644109

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