Article

Combined stem cell and predictive models reveal flavin cofactors as targets in metabolic liver dysfunction

2024-10-11

Abstract excerpt

Drug discovery for multifactorial diseases like metabolic dysfunction-associated steatotic liver disease (MASLD) remains challenging due to inadequate models and untargeted drug screenings. We combined stem-cell-based modeling with computational drug predictions identifying flavin pathways as therapeutic targets in MASLD. For disease stage-specific discovery, we established a MASLD testing model, compounding metab...

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Literature Corpus work: f392988c-3a95-5b3d-bba3-5ef5c19787b0
DOI: 10.1101/2024.10.10.617610

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