Article

Inhibiting DPP4 activity protects hiPSC-derived steatotic HLCs by supporting fatty acid and purine metabolism and dampening inflammation

2025-01-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Metabolic dysfunction-associated steatotic liver disease (MAFLD) has a high prevalence and high co-morbidity for other diseases. Due to the complexity of this multifactorial disease, therapy options are still rather limited. We employed an <italic>in vitro</italic> pluripotent stem cell-based model to decipher basic disease-associated molecular pathways and to st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd91c85a-d115-5d67-a8fc-ceead0a341c9
DOI: 10.21203/rs.3.rs-5660983/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibiting DPP4 activity protects hiPSC-derived steatotic HLCs by supporting fatty acid and purine metabolism and dampening inflammationDOI 10.21203/rs.3.rs-5660983/v1Read

DPP4 inhibition affects metabolism and inflammation associated pathways in hiPSC-derived steatotic HLCsSemantic proximity Read

Concise Review: Current Status and Future Directions on Research Related to Nonalcoholic Fatty Liver DiseaseSemantic proximity Read

Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem CellsSemantic proximity Read

MASLD-Induced Liver Micro-Organoids Mimics Clinical Observations of Impaired Vitamin D SynthesisSemantic proximity Read

<i>Patolakaturohiniyadi Kashayam</i> , exerts anti-steatotic and anti-obesogenic effects via coordinated regulation of lipid metabolism, inflammation, and incretin signallingSemantic proximity Read

Characterization Of Human Pluripotent Stem Cell-Derived Hepatocytes With Adult Features And Potential For Modeling Metabolic DiseasesSemantic proximity Read

Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision TherapySemantic proximity Read

Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease: Current Progress and ChallengesSemantic proximity Read

hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver.Semantic proximity Read

Advancements in Disease Modeling and Drug Discovery Using iPSC-Derived Hepatocyte-like CellsSemantic proximity Read

Novel 3D Approach to Model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem CellsSemantic proximity Read

Combined stem cell and predictive models reveal flavin cofactors as targets in metabolic liver dysfunctionSemantic proximity Read