Article
En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.
Cell - 27 Oct 2022
Kimura Masaki, Iguchi Takuma, Iwasawa Kentaro, Dunn Andrew, Thompson Wendy L, Yoneyama Yosuke, Chaturvedi Praneet, Zorn Aaron M, Wintzinger Michelle, Quattrocelli Mattia, Watanabe-Chailland Miki, Zhu Gaohui, Fujimoto Masanobu, Kumbaji Meenasri, Kodaka Asuka, Gindin Yevgeniy, Chung Chuhan, Myers Robert P, Subramanian G Mani, Hwa Vivian, Takebe Takanori
Abstract excerpt
Genotype-phenotype associations for common diseases are often compounded by pleiotropy and metabolic state. Here, we devised a pooled human organoid-panel of steatohepatitis to investigate the impact of metabolic status on genotype-phenotype association. En masse population-based phenotypic analysis under insulin insensitive conditions predicted key non-alcoholic steatohepatitis (NASH)-genetic factors including...
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