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Article

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

4 Oct 2023

Abstract excerpt

Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of liver disease that poses a global health threat because of its potential to progress to advanced fibrosis, leading to cirrhosis and liver cancer. Recent advances in single-cell methodologies, refined disease models, and genetic and epigenetic insights have provided a nuanced understanding of MASH fibrogenesis, with substantial cellular...

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PMID: 37792957
DOI: 10.1126/scitranslmed.adi0759

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