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The Divergent 3D Genome Landscapes of Aging and Neurodegenerative mouse models

2025-11-10

Abstract excerpt

Chromatin structure is essential for gene regulation and genome stability, and neurons must preserve their 3D genome organization throughout life. This structure gradually deteriorates with aging and is further disrupted in neurodegenerative diseases. To investigate whether aging and neurodegeneration share early chromatin changes or diverge, we performed Hi-C on cortical neurons from adult, aged, and brain-specif...

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Literature Corpus work
84701c27-aafe-58ae-b1bc-cc815d62a666
DOI
10.1101/2025.11.10.687599
Open publication

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The Divergent 3D Genome Landscapes of Aging and Neurodegenerative mouse modelsDOI 10.1101/2025.11.10.687599
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