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Article

Deciphering aging at three-dimensional genomic resolution

25 May 2022

Abstract excerpt

Aging is characterized by progressive functional declines at the organismal, organic, and cellular levels and increased susceptibility to aging-related diseases. Epigenetic alteration is a hallmark of aging, senescent cells show epigenomic changes at multiple scales, such as 3D genome reorganization, alterations of histone modifications and chromatin accessibility, and DNA hypomethylation. Chromosome conformation...

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PMID: 37193050
DOI: 10.1016/j.cellin.2022.100034

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